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KMID : 0390019930030010050
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Pediatric Allergy and Respiratory Disease
1993 Volume.3 No. 1 p.50 ~ p.58
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The effect of prednisolone on serum theophylline concentration in korean pediatic patients with asthma
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정혜영/Charies D.Sands
이희정/윤운기/오지섭/류환선/손기호
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Abstract
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Theophylline is widely used in pediatric patients for the treatment of asthma and neonatal apnea. To achieve adequate bronchodilation and avoid toxicity, it is generally accepted that the serum theophylline concentration should be maintained
between 10
and 20㎍/ml. Concentrations greater than 20㎍/ml are associated with an increased incidence of toxicity.
Clinical effectiveness and toxicity are clearly related to the serum concentrations. Thus, it is important to understand factors which might alter theophylline pharmacokinetics, Prednisolone has been reported to both in crease and decrease
theophylline
serum concentrations.
Clinical experience at our hospital(one case) suggested that there might be an interaction between prednisolone and theophylline that can potentially results in clinically significant changes in theophylline serum concentrations.
Thus, we studied eleven asthmatic children, who were admitted to out hospital and received oral sustained release theophylline and prednisolone. The mean serum theophylline concentration of single therapy group(phase I) was 8.10㎍/ml and of
concomitant
administered prednisolone group()phase II) was 8.39 ㎍/ml.
On the basis of serum theophylline concentrations, we had taken the volume of distribution(Vd), half life(t1/2) and calculated clearance(C1), in each of phase I and II. The mean clearance of phase I was 67.37ml /kg /hr and of phase II was 67.85ml
/kg
/hr.
The difference between mean serum theophylline concentration and clearance in the single therapy group(phase I) compared with concomitant administered prednisolone therapy group(phase II) was not statistically significant.(p>0.05).
This suggests that prednisolone does not affect the metabolism of theophylline and does not alter serum concentration of theophylline serum theophylline concentration and clearance.
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